Patient Recruitment

TOPS Recruitment

558 infants have been recruited to the trial. Recruitment closed in July 2015 and participants are continuing in follow up for the trial.

Country Recruiting Centre Number of Patients Randomised
Brazil University of São Paulo (HRAC Bauru) 165
Denmark Copenhagen Cleft Palate Centre, Copenhagen 19
Århus Speech and Hearing Institute, Århus 26
Norway Oslo University Hospital, Oslo 30
Sweden Helse Bergen HF, Bergen 19
Malmö University Hospital, Malmö 28
Göteborg University, Goteborg 6
Karolinska University Hospital, Stockholm 13
University of Linköping, Linköping 7
Umeå University, Umeå 4
Uppsala University, Uppsala 11
United Kingdom Royal Manchester Children’s Hospital, Manchester 37
Alder Hey Children’s NHS Foundation Trust, Liverpool 24
Royal Belfast Hospital for Sick Children 3
Birmingham Children’s Hospital, Birmingham 23
Royal Victoria Infirmary, Newcastle 41
University Hospitals Bristol NHS Foundation Trust, Bristol 26
Morriston Hospital, Abertawe Bro Morgannwg University Hospital Board, Swansea 6
Leeds General Infirmary, Leeds 25
Royal Hospital for Sick Children, Glasgow 15
Royal Hospital for Sick Children, Edinburgh 12
Salisbury NHS Foundation Trust, Salisbury 9
The Children’s Hospital, John Radcliffe Hospital, Oxford 9
Total 558

Recruiting sites


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University of Liverpool
LCTC - Liverpool Clinical Trials Centre
University of Manchester

The trial is sponsored by the University of Manchester and funded by the National Institute of Health, National Institute for Dental and Craniofacial Research (NIH-NIDCR). TOPS is coordinated by the University of Manchester (Administrative Centre) and the Liverpool Clinical Trials Centre at the University of Liverpool (Data Coordinating Centre).

© 2021 LCTC, a division of the University of Liverpool