Publications

Research Articles

  • Conroy, E.J., Cooper, R., Shaw, W. et al. A randomised controlled trial comparing palate surgery at 6 months versus 12 months of age (the TOPS trial): a statistical analysis plan. Trials 22, 5 (2021). https://doi.org/10.1186/s13063-020-04886-y
  • Christina Persson , Elizabeth J. Conroy , Carrol Gamble , Anna Rosala Hallas , William Shaw & Elisabeth Willadsen (2021) Adding a fourth rater to three had little impact in pre-linguistic outcome classification, Clinical Linguistics & Phonetics, 35:2, 138-153 DOI: 10.1080/02699206.2020.1758793
  • Elisabeth Willadsen, Christina Persson, Kathryn Patrick, Anette Lohmander & D. Kimbrough Oller (2020) Assessment of prelinguistic vocalizations in real time: a comparison with phonetic transcription and assessment of inter-coder-reliability, Clinical Linguistics & Phonetics, 34:7, 593-616, DOI: 10.1080/02699206.2019.1681516
  • Shaw W, Semb G, Lohmander A, et al Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age BMJ Open 2019;9:e029780. doi: 10.1136/bmjopen-2019-029780
  • Elisabeth Willadsen, Christina Persson & Duncan Appelbe (2018) A software program to assist coding of prelinguistic vocalizations in real time, Clinical Linguistics & Phonetics, 32:10, 972-978, DOI: 10.1080/02699206.2018.1463396

Conferences

Abstracts and Presentations

International conference in clinical linguistic and phonetics in Glasgow, Scotland (postponed until June 2021 due to COVID-19)
  • Assessment of canonical babbling status in infants with cleft palate: agreement between parents and speech therapists in 484 infants in the randomised control trial, Timing of Primary Surgery for Cleft Palate (TOPS). Professor Elisabeth Willadsen (Core Speech Team)
  • Agreement between two methods for classification of canonical babbling status in 484 infants born with cleft palate in the randomised control trial, Timing of Primary Surgery for Cleft Palate (TOPS). Professor Elisabeth Willadsen (Core Speech Team)
  • A descriptive sub-study of syllable inventory in 12-months-olds with isolated cleft palate. Results from 484 infants in an international RCT, Timing of Primary Surgery forcleft palate (TOPS). Associate Professor Christina Persson (Core Speech Team)
Inovações do tratamento clínico à bioengenharia de tecidos nas malformações congênitas, São Paulo, Brazil (November 2020) 5th International Clinical Trials Methodology Conference in Brighton, UK (October 2019)
  • Measuring speech development in infants: methodological considerations based on experiences within the TOPS trial. Miss Rachael Cooper (Trial statistician)
European Cleft Palate Craniofacial Association in Utrecht, Netherlands (June 2019)
  • Assessment of canonical babbling status in 485 infants with CP: agreement between Speech Language Therapists and parents. Professor Elisabeth Willadsen
  • A descriptive sub-study of syllable inventory in 12-months-olds with isolated cleft palate. Associate Professor Christina Persson
Professor Bill Shaw, (The Chief Investigator) has presented the following abstracts:
  • Tridentate Reunion, Jersey (October 2018) – “Progress in Cleft Care”
  • 70th Anniversary of Helsinki Cleft Centre, Finland. (November 2018 – “Lessons learned from RCTs of Cleft Surgery”
  • 3rd ERN CRANIO Meting, Sweden (November 2018) – “Collaborative research and clinical trials in cleft care”
17th International Clinical Phonetics and Linguistics Association Conference in Malta (October 2018)
  • Development of a reliable method for assessing babbling milestones in real time. Professor Elisabeth Willadsen
Craniofacial Society of Great Britain and Ireland in Birmingham, UK (April 2018)
  • Challenges and progress in an international RCT of children with CP (TOPS); Overview of an ongoing international RCT. Professor Elisabeth Willadsen.
  • TOPS (Timing Of Palate Surgery for Cleft Palate): past, present and future; A descriptive study of syllable inventory in 12-months-olds with isolated cleft palate. Professor Elisabeth Willadsen. 17th International Clinical Phonetics and Linguistics Association Conference in Malta (October 2018)
Swedish National Cleft Meeting in Gothenburg, Sweden (October 2017)
  • Timing Of Primary Surgery for cleft palate (TOPS). Associate Professor Christina Persson Craniofacial Society of Great Britain and Ireland in Birmingham, UK (April 2018)
International Cleft Congress in Chennai, India (February 2017)
  • Syllable inventory in 12-months-olds with isolated cleft palate, a descriptive study (poster presentation) Associate Professor Christina Persson
  • Naturalistic assessment in real time of prelinguistic vocalizations by infants with cleft palate, a methodological study. Professor Elisabeth Willadsen

Collaborators

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University of Liverpool
LCTC - Liverpool Clinical Trials Centre
University of Manchester

The trial is sponsored by the University of Manchester and funded by the National Institute of Health, National Institute for Dental and Craniofacial Research (NIH-NIDCR). TOPS is coordinated by the University of Manchester (Administrative Centre) and the Liverpool Clinical Trials Centre at the University of Liverpool (Data Coordinating Centre).

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